Genetic link to heart disease in Indian population

InnoHEALTH Magazine — Fri, 27 Apr 2018 08:18:07 +0000

A team of Indian researchers have discovered that carriers of a set of genetic variants in the Chromogranin A (CHGA) gene called‘CHGA promoter haplotype2’ may be at higher risk for cardiovascular and metabolic disorders. An estimated 35 to 40 percent of Indian population may carry this genetic variant.

The study is based on analysis of genomic DNA samples from over 750 individuals from Indian population. The research findings have been published in the Journal of Biological Chemistry.

[vc_empty_space]

Though the CHGA promoter haplotypeis present in other ethnic populations, it occurs more frequently in population of South Asian ancestry. “It is a protein of neuroendocrine origin and is secreted along with hormones like catecholamines. Earlier studies had suggest edits role in regulation of cardiovascular and metabolic diseases but there was no data aboutit in South Asian population,” said Lakshmi Subramanian, first author of this paper.

“Westudied genomic DNA of Indians and discovered a specific set of changes in the CHGA genesequence called Haplotype2 which contributed to increased CHGA gene expression, and ultimately increased CHGA protein levels in plasma. When the clinical parameters of those in the study were compared, Haplotype2 carriers displayed higher levels of metabolic and cardiovascular traits like plasma glucose, blood pressure and body mass index,” explained Dr. Nitish R. Mahapatra, Professor at IIT Madras.

[vc_single_image image=”3831″ img_size=”500×300″ alignment=”center” onclick=”link_image”]

[vc_single_image image=”3832″ img_size=”500×300″ alignment=”center” onclick=”link_image”]

However, he said, these results need further validation in animal models as well as large scale studies in individuals with metabolic syndrome. “We hope these findings would help unravel biological pathways and mechanisms underlying these complex diseases and would help in the development of therapeutic as well as preventive strategies,” said Dr. Mahapatra.

“Basic research in cardiovascular biology is in a very nascent stage in India with only a handful of researchers working in this field. This new study significantly contributes towards understanding molecular basis of cardiovascular and metabolic diseases. This is a fast emerging area with tremendous therapeutic and diagnostic potential,” commented Dr Shyamal K. Goswami, a professor at School of Life Science, JNU, who is not connected with the study.

The study was led by Dr. Mahapatra in a collaborative effort with Dr. Ajit S. Mullasari at Madras Medical Mission, Chennaiand Dr. Madhu Khullar at PGIMER, Chandigarh.

(Article shared from India Science Wire)

Want to write for InnoHEALTH? send us your article at magazine@innovatiocuris.com

Read all the issues of InnoHEALTH magazine:
InnoHEALTH Volume 1 Issue 1 (July to September 2016) – https://goo.gl/iWAwN2
InnoHEALTH Volume 1 Issue 2 (October to December 2016) – https://goo.gl/4GGMJz
InnoHEALTH Volume 2 Issue 1 (January to March 2017) – https://goo.gl/DEyKnw
InnoHEALTH Volume 2 Issue 2 (April to June 2017) – https://goo.gl/Nv3eev
InnoHEALTH Volume 2 Issue 3 (July to September 2017) – https://goo.gl/MCVjd6
InnoHEALTH Volume 2 Issue 4 (October to December 2017) – http://amzn.to/2B2UMLw
InnoHEALTH Volume 3 Issue 1 (January to March 2018) – https://goo.gl/fksdQx
InnoHEALTH Volume 3 Issue 2 (April to June 2018) – https://goo.gl/grbtRo

Connect with InnovatioCuris on:
Facebook: https://www.facebook.com/innovatiocuris
Twitter: https://twitter.com/innovatiocuris
LinkedIn: https://www.linkedin.com/groups/7043791
Stay updated about IC, visit: www.innovatiocuris.com

The post Genetic link to heart disease in Indian population appeared first on InnoHEALTH magazine.

Adopting new technology to cross physical barriers

InnoHEALTH Magazine — Wed, 14 Feb 2018 06:05:14 +0000

High profile panel of speakers from different fields of health and medical facilities explored the option of inducing innovations and new technology in the operations of hospitals and clinics, at the InnoHEALTH 2017 conference in New Delhi.

Keynote Address: Dr. Vijay Agarwal,
Moderator: Dr. Arati Verma
Speakers
· Prof. A.K Gupta,
· Partha Dey,
· Surjeet Thakur,
· Prof. Arti Maria

[vc_single_image image=”3322″ img_size=”500×300″ alignment=”center” onclick=”link_image”][vc_single_image image=”3325″ img_size=”500×300″ alignment=”center” onclick=”link_image”]

Hospitals are the core of health and medical care and adaptation of new technology and innovations will make the biggest difference to our medical needs while improving the health conditions of all.

Highlighting the concern of data security and reluctance to depend on technology because of that concern, the keynote speaker for the first session Dr. Vijay Agarwal shared his views on the subject emphasizing on the fact that technology is rolling out at a very fast pace. Stating an example of landline telephones that took more than 100 years to reach the one billion mark of users, was reduced to less than 20 years for mobile technology to do the same. This way he highlighted the fact that newer technology will be very rapid in implementation requiring hospitals and clinics to adapt and be prepared to utilize it rather than be apprehensive about it.

Professor AK Gupta of the esteemed PGI Hospital in Chandigarh, also, supported this view and shared his personal experiences and experimentation with management and administration of the hospital. He emphasized that it’s not just in the medical and clinical field that we have to embrace innovations and technology, but in fact it will fetch very positively encouraging results if adopted in the management and administration of hospitals. He shared his views on reducing the time stay of patients in hospitals by means of using an innovative approach provided by tailored software and mobile apps. These efforts were recognized by the hospital; national level authorities and even internationally and was rightly awarded for this approach. He concluded his speech by asserting that you don’t have to discover new technology, but innovative utilization of existing technology can also provide very good results.

Touching the humane element in the hospitals, Prof Arti Maria of RML Hospital shared her experiences of involving mothers and non-hospital staff in caring for the young ones in ICU units. “A soft touch by the mothers, who are otherwise distanced outside the ICU units, has resulted on faster recovery of infants in the ICU.”

“In fact, this experimentation has also resulted in enhanced confidence of mothers and improved their social status with respect to their husbands, families and the social fabric as such.” Prof Maria, who specializes in Neonatology as Head of that Department is keenly working with other authorities beyond the hospital to promote this concept and is getting very encouraging results from hospitals, and relevant bodies.

[vc_single_image image=”3327″ img_size=”500×300″ alignment=”center” onclick=”link_image”]

[vc_single_image image=”3328″ img_size=”500×300″ alignment=”center” onclick=”link_image”]

Partha Dey, with years of experience at IBM shed some light on the subject of innovations with the simplicity that the IBM is known for. The three products and services of IBM, Watson, Block Chain and Cloud data are the way forward, according to Mr. Dey, Healthcare Leader and SME and IBM, India.

Watson, according to Mr Dey, is the most innovative friend for health care workers and doctors alike, as it understands many languages, including regional and Oncology. This helps medical staff to interpret and diagnose ailments with a high grade of accuracy and ease. Watson can, not only, analyze and conclude at a faster pace, but can also eliminate human error contributed in the form of emotional stress and personal bias.

Block Chain, on the other hand is the best mode of data utilization and can contribute to tracking of product and their status. Block Chain can also help eliminate counterfeit medicines by clever tracking of products and their batches.

IBM is constantly pushing the boundaries of innovations with introduction of new products and services. Watson and Block Chain are latest in the field of health and medical welfare.

In totality, the high profile panel of speakers from different fields of health and medical facilities explored the option of inducing innovations and new technology in the operations of hospitals and clinics beyond clinical procedures, leading to heightened efficiency and operational advantages resulting in a healthier society and population at large.

[vc_cta h2=”Dr. Arati Verma”]

“Artificial intelligence has been there since ages. But big corporates throw things at you to claim that they have something new and latest. Most artificial intelligence uses software and the software is as good as the users, which means even the artificial intelligence needs human intervention for efficient execution. In the field of health and medical, AI is even more depending on the involvement and interpretation of human beings.”

[/vc_cta]

[vc_cta h2=”Prof. Arti Maria”]

“Innovation doesn’t have to be in technology alone. Anything that has not been measured doesn’t mean it doesn’t exist. So if stress on a child straight out of the womb and placed in an ICU has not been measured for any reason; it does not mean that the child is not undergoing any stress. Our new approach to introduce mother and family members in the ICU area has shown very encouraging results that resulted in speedy recovery by the child.”

[/vc_cta]

[vc_cta h2=”Siddharth Sangwan”]

“We have been hearing of tele-medicine has been from the Nehru and Indira Era. But what is accomplished so far is very less. We have now integrated the tele-medicine system where the doctor explains the report to the patient and in the process takes the customer/patient in a walk through his report and diagnosis. Next step of tele-medicine will be to integrate Artificial Intelligence so that patients can contribute to the clinical process and recover faster, with the additional help of doctors and medicines.”

[/vc_cta]

Want to write for InnoHEALTH? send us your article at magazine@innovatiocuris.com

The post Adopting new technology to cross physical barriers appeared first on InnoHEALTH magazine.

Chandigarh Archives - InnoHEALTH magazine

Genetic link to heart disease in Indian population

Adopting new technology to cross physical barriers