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		<title>GRB IJSR SALVATION office Light  Case Study</title>
		<link>https://innohealthmagazine.com/2022/advertorial/grb-ijsr-salvation-office-light-case-study/</link>
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		<pubDate>Mon, 09 May 2022 10:13:58 +0000</pubDate>
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					<description><![CDATA[<p>International Journal of Science and Research (IJSR)&#160;ISSN: 2319-7064&#160;SJIF (2022): 7.942 Cognitive Performance, Zeitgeber Entrainment Acknowledgement, Mitochondrial Activity, Work Hour Melanopic-Circadian Alignment and Improvement in Social Behaviour: (Includes) A Prospective Study...</p>
<p>The post <a href="https://innohealthmagazine.com/2022/advertorial/grb-ijsr-salvation-office-light-case-study/">GRB IJSR SALVATION office Light  Case Study</a> appeared first on <a href="https://innohealthmagazine.com">InnoHEALTH magazine</a>.</p>
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<p><strong>International Journal of Science and Research (IJSR)&nbsp;</strong><br><strong>ISSN: 2319-7064&nbsp;</strong><br><strong>SJIF (2022): 7.942</strong></p>



<h2 class="wp-block-heading" style="font-size:25px">Cognitive Performance, Zeitgeber Entrainment Acknowledgement, Mitochondrial Activity, Work Hour Melanopic-Circadian Alignment and Improvement in Social Behaviour: (Includes) A Prospective Study of up to 19 Office Goers: Salvation Series</h2>



<p>An insight to the facts, research, design and specification of the office luminaires for the circadian alignment, healthy LQI- Lighting quality&nbsp; index&nbsp;</p>



<p><strong><em>Abstract:</em></strong> <em>The need for Healthy (Forming the parameters of Light Quality Index-LQI, Physiological Evidence based office lighting),&nbsp; with smart controls. It all began with the inquisitiveness that how light as a zeitgeber influences the molecular mechanism are sensing&nbsp; the environment for the time cues? How circadian is disrupted or aligned, what is the connection between immune system and light, why&nbsp; there are chances of being prone to some types of cancer-with relation to light, how retina gets damaged, effects of white LED exposure&nbsp; on retinal pigment epithelium, relationship of metabolism and muscular atrophy with respect to light and many of these inquisitiveness.</em></p>



<h2 class="wp-block-heading" style="font-size:22px"><strong>1. Introduction</strong></h2>



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<p>The idea that there can be an “unambiguous technique” for&nbsp; human-bio favourable lighting like tenable white without&nbsp; considering the bioblue transition to the dim grey&nbsp; appearanceand in the absence of other non-visible and&nbsp; visible parameters is totally unrealistic, because of the non&nbsp; synchronisation of the indoor skylight dynamics in&nbsp; concurrence with the outdoor skylight dynamics,&nbsp; tremendous variability between individuals based on their&nbsp; age, genetics, environmental factors, individual physiology,&nbsp; eating habits, and wake up or the sleep timings and our&nbsp; behavioural aspects. The harmony of the glands is accomplished by constantly&nbsp; synchronizing our body’s atoms, glands, genes, molecules,&nbsp; cells hormones in alignment of time cues- the LIGHT.</p>
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<h2 class="wp-block-heading" style="font-size:22px"><strong>2. <strong>How the project started?</strong></strong></h2>



<p>When DPA moved its Mumbai office to a new location they enlisted healthy lighting Design, their in-house group of&nbsp; illuminating experts, to solve the projects lighting&nbsp; challenges. The new space in the Ahmedabad’s based Office&nbsp; Tower is a conventional mix of open-area workstations,&nbsp; private offices and conference rooms with low 11’ 5”&nbsp; ceilings throughout.</p>



<p>The project’s lighting objectives were established “to&nbsp; provide wellness, healthy, interactive, an ergonomic and&nbsp; visually luminance balanced workspace,” means, “That&nbsp; evenly illuminating the ceilings, walls and work surfaces,&nbsp; while CS &amp; EML levels the space and lighting should help&nbsp; the occupants with the better cognitive functions,&nbsp; minimizing glare and unwanted reflections.”&nbsp;Considering the limitations of traditional recessed &amp; suspended fixtures, these objectives were easier said than&nbsp; done. The challenge was also to create aesthetically bright&nbsp; environments</p>



<p><strong>Facts:</strong></p>



<p>Until now we were concerned with defined lux levels,&nbsp; tuneable white light, UGR, CRI and the w/soft. Now there’s&nbsp; a product that offers controlled CS, CR ratio, EML, retino hypothalamic activation to trigger pineal &amp; pituitary glands&nbsp; with the designed SPD for special bio-red &amp; bio-blue&nbsp; technology in line with irradiance value to help out&nbsp; physiology of the body also helping our 3-neurotransmitters,&nbsp; cognitive functions brightness, uniform distribution and&nbsp; exceptional energy performance.</p>



<p><strong>Volume 11 Issue 4, April 2022</strong> <br><strong><a href="https://www.ijsr.net/" target="_blank" rel="noreferrer noopener">www.ijsr.net&nbsp;</a></strong><br>Licensed Under Creative Commons Attribution CC BY<br>Paper ID: SR22416151122 DOI: 10.21275/SR22416151122 807</p>



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<figure class="wp-block-image size-full"><img decoding="async" width="167" height="86" src="//i2.wp.com/innohealthmagazine.com/wp-content/uploads/2022/05/GRB-IJSR_1.png" alt="" class="wp-image-13992"/><figcaption>Bio red+Bio blue with irradiance controlled values along&nbsp; with spd’s tunable-2700K-5700K</figcaption></figure>
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<p><strong>International Journal of Science and Research (IJSR)&nbsp;</strong><br><strong>ISSN: 2319-7064&nbsp;</strong><br><strong>SJIF (2022): 7.942</strong></p>
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<h2 class="wp-block-heading" style="font-size:22px"><strong>3. <strong><strong>Proposed Standards for Light Quality</strong></strong></strong></h2>



<p>Being tenacious and ascertaining a healthier lighting space&nbsp; always requires a process of trading off some aesthetical and&nbsp; volumetric aspects of the space for healthier future gains.&nbsp;&nbsp;However, this has been a very thick proposition from an&nbsp; architectural and interior point of view, especially in the&nbsp; office and the residential segments.&nbsp;&nbsp;</p>



<p>We need to strategies w.r.t. legislative to be proposed and&nbsp; implemented regarding <strong>LQI-INDOOR LIGHT QUALITY&nbsp; INDEX.</strong>, as there is an exponential rise in severe neuro and&nbsp; retinal disorders as well as the related illnesses. This is due&nbsp; to the inappropriate forms and sources of light that are&nbsp; contributing negatively to our health are:&nbsp;</p>



<ul class="wp-block-list"><li>Retinal damage&nbsp;</li><li>Brain fatigue&nbsp;</li><li>Stress&nbsp;</li><li>Migraine&nbsp;</li><li> Insomnia&nbsp;</li><li>EFD&nbsp;</li><li>Cancer</li><li>Obesity&nbsp;</li><li>Age related Macular degeneration&nbsp;</li><li>Skin diseases&nbsp;</li></ul>



<p><strong>3.1 How does the LQI work?</strong></p>



<p>The standard of LQI can be broadly defined as the&nbsp; combination of visible and non-visible parameters&nbsp; (Wavelength, frequency, radiance, and irradiance, and&nbsp; photons, visual and non-visual acuity) for our health and&nbsp; wellbeing. The higher the LQI value, the greater the levels&nbsp; of these healthy parameters inducing the physiological and&nbsp; psychological benefits to the inhabitants For example, an&nbsp; LQI value of 80 (out of 100) represents good healthy&nbsp; lighting with respect to circadian alignment, ATP&nbsp; production, serotonin levels, melatonin balance and visual&nbsp; acuity as a rejuvenated space.&nbsp;</p>



<p>The LQI can be categorised into three different zones. Each&nbsp; category corresponds to a different level of health and&nbsp; wellbeing concern. Each category also has a specific&nbsp; features of the light as a product, components, is&nbsp; deliverables in terms of efficacy, lumens, flicker ratio, THD,&nbsp; Gamut values, CCT ratio, CRI, α-opic ratio EML, CS etc&nbsp; along with the presence of radiance and irradiance values,&nbsp; non-visible wavelength and its corresponding ranges&nbsp; subjected to the physiological. The purpose of the LQI is to help people know how the&nbsp;&nbsp;Light quality impacts their health and wellbeing. It must&nbsp;&nbsp;<strong>NOT </strong>contribute to</p>



<ol class="wp-block-list"><li> Retinal fatigue&nbsp;</li><li>Brain fatigue&nbsp;</li><li> Migraine</li></ol>



<p>values and limits..<br>It must <strong>HAVE </strong>mentioned outcomes&nbsp;</p>



<ul class="wp-block-list"><li> Rejuvenation&nbsp;</li><li>Circadian alignment and not the drive&nbsp;</li><li> Improvements in the cognitive skills&nbsp;</li><li>Activation of Solitrol to generate Vitamin D </li><li>Better mitochondrial balance while having the presence&nbsp; of NIR*/FIR*&nbsp;</li></ul>



<p><strong>3.2 Why is LQI important?</strong></p>



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<p>The business of lighting has grown Multi-folds over the past&nbsp; one decade and so do the technical understanding on the&nbsp; same embraced with the skills with respect to creativity, but&nbsp; the fundamentals of physiology in relation to light is still to&nbsp; reach those numbers.&nbsp;&nbsp;LQI is much more than just furnishing an appropriate&nbsp; quantity of light like lux levels, efficacies, R values, CRI,&nbsp; CCT, Macadam step etc&#8230;&nbsp;</p>



<p>There are many psychological as well as physiological&nbsp; factors that has to be covered under of lighting quality index&nbsp; (LQI). Lighting quality cannot be expressed simply in&nbsp; terms of photometric measures nor can there be a self&nbsp;explicit ways applicable formula for good quality lighting,&nbsp; but surely the lighting quality as expected and desired must&nbsp; be HEALTHY and not just smart or cost effective.</p>
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<p><strong>Volume 11 Issue 4, April 2022&nbsp;</strong><br><strong><a href="https://www.ijsr.net/" target="_blank" rel="noreferrer noopener">www.ijsr.net</a>&nbsp;</strong><br>Licensed Under Creative Commons Attribution CC BY&nbsp;<br>Paper ID: SR22416151122 DOI: 10.21275/SR22416151122 808&nbsp;</p>



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<p><strong>International Journal of Science and Research (IJSR) </strong><br><strong>ISSN: 2319-7064&nbsp;</strong><br><strong>SJIF (2022): 7.942</strong></p>



<p><strong>3.3 Objectives of Light Quality Index (LQI)</strong></p>



<p>The DNA of our lighting industry changed with the arrival&nbsp; of LEDs. Thus our parameters w.r.t. the biology has to be&nbsp; restructured. The LQI primarily works on the contribution of&nbsp; lighting parameters (visible and non-visible) on human (the&nbsp; occupants) physiology and the psychology.&nbsp;&nbsp;Depending upon the indoor spaces and the layouts with&nbsp; respect to the topography the LQI parameters can be reset.&nbsp; For instance, LQI parameters for South Pole for an indoor or&nbsp; outdoor application will differ from the inhabitants of North&nbsp; Pole. The study of the sets of individuals is very crucial as&nbsp; the physiology of sets of human beings will differ and thus&nbsp;there cannot be one single yardstick to govern LQI.&nbsp;To make it easier to understand, the LQI can have&nbsp; mentioned pathways to be formed:&nbsp;</p>



<ul class="wp-block-list"><li>Affects of different spectrums on human health </li><li>By an appropriate use of lighting controls, tuneable white&nbsp; light blending with biored* and bioblue* lights to induce&nbsp; replica of the nonvisible and visible parameters of light&nbsp; {dawn, full sunny day &amp; dusk timelines.}&nbsp;</li><li> Combination of appropriate forms of LEDs. </li><li>Avoiding the direct view of light sources, incorporating a&nbsp; lighting design to reduce the number of lights in a&nbsp; pragmatic manner.&nbsp;</li><li>Allowing the maximum parameters of Sunlight through&nbsp; the glass enveloped buildings&nbsp;</li></ul>



<p><strong>Need for an appropriate design for office lighting: SALVATION* series CAMA&nbsp;</strong> &#8211; Girish Bhardwaj, Tashi Aggarwal</p>



<p>It’s the need for the hour to re think and adapt lighting&nbsp; product design and the lighting consultancy which must&nbsp; contribute towards the Circular economy and biodiversity,&nbsp; health and wellbeing parameters rather lux or illuminance,&nbsp; cost benefits or CAPEX / OPEX point of views.&nbsp;</p>



<p>The design from <strong>SALVATION* seriesCAMA </strong>(<strong>C</strong>ircadian&nbsp; <strong>A</strong>lignment &amp;<strong>M</strong>itochondrial <strong>A</strong>lgorithm) based delivers both&nbsp; visual and non-visual benefits with respect to physiology,&nbsp; luminance / illuminance, visual acuity for the occupants. We&nbsp; have adopted the methodology towards the optimization for&nbsp; efficacy, LOR, TM-30 regulations, CRI, EML, CS and need&nbsp; for boosting mitochondrial activities to boost our immune&nbsp; systems as well as our cell regeneration while maintain the&nbsp; melatonin/ cortisol ratios.&nbsp;</p>



<p>Algorithms are based on the astronomical clocks for&nbsp; resetting of the desired SPDs and colour corrections with the&nbsp; an appropriate form of BIO BLUE* and Bio RED*</p>



<p><strong>Introduction to the Salvation series:</strong></p>



<p>Apart from the visual perception or the acuity, it is very well&nbsp; established that light is the governor of our hormones and it&nbsp; is very essential to maintain the harmony amongst the&nbsp; glands, hormones and the neurotransmitters.&nbsp;For example, our biological clock is regulated by the circadian and diurnal rhythms through the intrinsically&nbsp; photosensitive retinal ganglion cells (ipRGCs) that transmit&nbsp; light stimuli to the suprachiasmatic nucleus (SCN) which&nbsp; governs our pituitary and pineal gland with negative&nbsp; transactional feedback loop systems.<em>.</em></p>



<p>Similarly, molecules which are chromophores’, absorbs the&nbsp; wavelengths emitted by the light source. There is an optical&nbsp; tissue window which varies from 600 nm to 1400 nm (&nbsp; infrared spectrum). The chroma force in tissues which&nbsp; absorbs the light energy. These chroma force are found in&nbsp; MITOCHONDRIA.&nbsp;MITOCHONDRIA, in these we have specific molecule&nbsp; known as Cytochrome C oxidase, which is responsible to&nbsp; produce energy within MITOCHONDRIA. This means&nbsp; Adenosine Tri Phosphate (ATP), which is the end product of&nbsp; energy correlation and is the fuel our cells need for&nbsp; transporting irons for metabolism.&nbsp;</p>



<p>As compared to the traditional lights in the name of&nbsp; HCVL/HCL/Circadian drive the phenomenon of these office&nbsp; lighting is different and advanced in terms of technology and&nbsp; health benefits as we are focussing more on the circadian&nbsp; alignment and physiological benefits* from the longer&nbsp; wavelengths.&nbsp;SPECTRAL OPTIMIZATION FOR CAMA was utmost&nbsp; essential. The Luminous efficacy w.r.t. lumens, irradiance&nbsp; and joules / seconds has been given the priority along with&nbsp; the EML/CS/TM-30-18 and CRI parameters.&nbsp;</p>



<p>Salvation is a modular, adaptive &amp; intelligent lighting tool&nbsp; designed for the biological wellbeing of the humans while&nbsp; meeting the visual needs of the occupants of any space.&nbsp;&nbsp;This luminaire is designed using the proprietary technology&nbsp; (patent pending) using specific wavelengths of light which&nbsp; are scientifically proven to aid to photo-:bio-stimulation and&nbsp; trigging cortisol, together with high quality LEDS which can&nbsp; be tuned to the required colour temperature.&nbsp;&nbsp;</p>



<p>The luminaire houses intelligent program embedded to tune&nbsp; to the circadian requirements of the occupants of a spaces&nbsp; along with triggering the photo stimulus at calculated&nbsp; intervals throughout the day.&nbsp;High quality electronics &amp; control ensures to meet stringent&nbsp; flicker and EMF emission norms which further makes the&nbsp; luminaire safe &amp; secure for daily usage . </p>



<p><strong>Light Source:</strong> Medical Grade LEDs of proprietary&nbsp; wavelengths, Tenable 2700-5500K&nbsp;&nbsp;<br><strong>System Power:</strong> 70 Watts excluding standby power CRI /&nbsp; GAI : &gt;90 / &gt; 78.9 (typical)&nbsp;<br><strong>Mounting:</strong> Ceiling Recessed for Grid / Gypsum / PoP type&nbsp; ceiling structure&nbsp;&nbsp;<br><strong>Dimension:</strong> L: 600 X W:600 X H:125mm&nbsp;&nbsp;<br><strong>Control Gear:</strong> Electronic In-Built PF &gt; 0.9 , THD &lt; 10% ,&nbsp; IEC Compliant for Safety , Performance, Flicker , &amp; EMF/I&nbsp; &#8211; Dimmable, Tunable via proprietary control software over</p>



<p><strong>Volume 11 Issue 4, April 2022&nbsp;</strong><br><strong><a href="https://www.ijsr.net/" target="_blank" rel="noreferrer noopener">www.ijsr.net&nbsp;</a></strong><br>Licensed Under Creative Commons Attribution CC BY&nbsp;<br>Paper ID: SR22416151122 DOI: 10.21275/SR22416151122 809&nbsp;</p>



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<p><strong>International Journal of Science and Research (IJSR) </strong><br><strong>ISSN: 2319-7064&nbsp;</strong><br><strong>SJIF (2022): 7.942</strong></p>



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<figure class="wp-block-image size-full"><img decoding="async" width="239" height="95" src="https://innohealthmagazine.comwp-content/uploads/2022/05/GRB-IJSR-SALVATION-office-Light.png" alt="" class="wp-image-14015"/><figcaption>Tunable White Tunable White 2700K 5500K&nbsp;&nbsp;<br>Bio Blue* Bio Red*<br></figcaption></figure>
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<p><strong>Study Objectives for the project as a case study to&nbsp; implement the research work:</strong></p>



<p>To examine the association between bio-red, bio blue,&nbsp; NzER, FzIR and swift switchovers of Kelvins (2700-5500K)&nbsp; during office hours.&nbsp;<br><strong>Methods:</strong> A total of 19 office goers who were subjected to SALVATION SERIES. From morning 9:30-10:00 AM were&nbsp; subjected with blubio+4000K trigger the pituitary gland&nbsp;<br><strong>From</strong> 10:00 AM-1:30 PM they were subjected under bio blue+5500K&nbsp;<br><strong>From</strong> 2:15 PM-2:30 PM they were subjected under bio-red&nbsp; (NzIR+680).&nbsp;<br><strong>From</strong> 2:30 PM &#8211; 4:30 PM they were subjected under bio&nbsp; blue+5500K&nbsp;<br><strong>From</strong> 4:30PM&#8211;5:30 PM they were subjected under 3000K&nbsp;</p>
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<p>The controlled (auto and manual) ways of implementation of&nbsp; bioblue* transition to the dim grey appearanceand vice&nbsp; versa to trigger either the pituitary or the pineal glands&nbsp; (depending upon the time of the day) in concurrence&nbsp; with the tuneable white spectrum (with controlled&nbsp; intensities of the light)was give utmost important along&nbsp; with the task lighting and lighting during the work break sessions.&nbsp;In the present study as baseline and were followed up to 25&nbsp; to 45 years of age. Sleep duration was categorized as ≤ 10&nbsp; hours,</p>



<p><strong>Introduction</strong></p>



<p>Because all light sources were adjusted to provide the same&nbsp; horizontal as well as vertical illumination from table till 25&nbsp; inches on a vertical plane (the standard measure that lighting&nbsp; designers use to illuminate indoor spaces), and because the&nbsp; spectral power distributions of the chosen LED light sources&nbsp; were significantly diverse, the intensity of total visible&nbsp;</p>



<p>Light entering the eye (measured vertically at eye level with&nbsp;the subjects seated at the conference table) varied between&nbsp; the light sources. This provided the opportunity to determine&nbsp; if the melatonin which was influenced by corneal light metrics (irradiance in μW/cm2, photon irradiance in&nbsp; photons/cm2/s, photopic illuminance in lux). Individual&nbsp; pupil sizes and macular pigment optical density were not&nbsp; measured and were not taken into account. There was a&nbsp; significant correlation between light intensity by any of&nbsp; these metrics and the melatonin results.</p>



<p>We next examined how well the most commonly used&nbsp; circadian lighting calculators, the circadian stimulus (CS;&nbsp; Rea and Figueiro, 2018), CIE melanopic irradiance (CIE 026S), and the closely related equivalent melanopic lux&nbsp; (EML) calculator the occupants were subjected under these&nbsp; conditions of variable LED light sources.&nbsp;</p>



<p>Apart from this the presence of NIR with the controlled&nbsp; ratios is utmost important for the applications like office&nbsp; lighting &amp; healthcare units. Thus its not only aligning the&nbsp; circadian rhythm but also to induce the physiological&nbsp; parameters though the fed form of energy available in LEDs,&nbsp; all thanks to the advancement in the field of lighting which&nbsp; definitely is improvising the missing LED fed frequencies&nbsp; and the wavelengths which are must for humans, when&nbsp; spending more than 60% of their time in their work&nbsp; respective places.&nbsp;</p>



<h2 class="wp-block-heading" style="font-size:22px"><strong>4. <strong><strong><strong>Analysis and implementation of the design&nbsp; and the luminaires</strong></strong></strong></strong></h2>



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<p><strong>Volume 11 Issue 4, April 2022&nbsp;</strong><br><strong>www.ijsr.net&nbsp;</strong><br>Licensed Under Creative Commons Attribution CC BY&nbsp;<br>Paper ID: SR22416151122 DOI: 10.21275/SR22416151122 810&nbsp;</p>
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<p><strong>International Journal of Science and Research (IJSR)&nbsp;</strong><br><strong>ISSN: 2319-7064&nbsp;</strong><br><strong>SJIF (2022): 7.942</strong></p>



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<h2 class="wp-block-heading" style="font-size:22px"><strong>5. Final Conclusion</strong></h2>



<p>a) It’s not only the tuneable white spectrum which helps the&nbsp; shifting gears in the levels of melatonin (or cortisol) but&nbsp; it’s the process of unification in the dynamics of white&nbsp; spectrum causing the appearance of the scattered blue to&nbsp; grey in the sky or vice versa (With respect to the&nbsp; luminance and illuminance in the entire outdoor space).</p>
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<p>b) We do not need any validations or research on this, if&nbsp; you want to experience, look up above the sky during&nbsp; dawn or dusk (Be there out in the open space at least 20&nbsp; minutes prior to dusk or dawn hours)…&nbsp;<br>c) Apart from the circadian alignment in few of the&nbsp; employees / occupants, the enhanced improvement in the&nbsp; behaviour and marked enhancements in the cognitive&nbsp; skills were also noticeable.&nbsp;<br>d) Lighting layout and the product design played a very&nbsp; vital role in biophilic design. The sense of rejuvenation&nbsp; was experienced by the occupants.&nbsp;<br>e) Finally a bold and appropriate step towards the&nbsp; contribution in circular economy while providing the&nbsp; lights on the rental basis.&nbsp;</p>



<h2 class="wp-block-heading" style="font-size:22px">6. <strong>Acknowledgements from the Client</strong></h2>



<p>The purpose of choosing an appropriate light and its effect&nbsp; for any building (indoors), is not only the involvement of&nbsp; commercial or technical aspects, but it’s the series of&nbsp; physiological &amp; neurobiological factors. The evident&nbsp; incremental in cognitive performance, reduced stress, better&nbsp; sleep nap &amp; over all acknowledgement of impact of time&nbsp; cues. The project’s lighting design was further complicated by its&nbsp; ambitions for energy performance. DPA was seeking a&nbsp; physiologists &amp; psychologists feedback with a voluntary&nbsp; system for wellness &amp; health.&nbsp;&nbsp;</p>



<p>We carried out the audit and the analysis for the same with&nbsp; some of the toughest assessing parameters, and adherence to&nbsp; CS026 With demands for quality visual ergonomics running&nbsp; up against restrictive energy codes,&nbsp;&nbsp;</p>



<p>DPA’s offices were precisely the kind of space that tests the&nbsp; limits of conventional lighting. “If we went with traditional&nbsp; recessed lighting, I knew we would have to compromise&nbsp; somewhere.”&nbsp; The research on wellness, health and physiology led DPA’s&nbsp; team to consider Salvation series™, a new family of&nbsp; recessed and suspended luminaries.&nbsp;My colleagues didn’t believe that a light can be a medicine&nbsp; to keep us away from many of visual and non-visual impacts&nbsp; on our health and body.&nbsp;They thought that the light is very bright and clean was the&nbsp; only solution&nbsp;</p>



<p>“People walk into our offices now and feel that they’re in&nbsp; the most appropriate, productive, stress free (limbic) &amp;&nbsp; natural environment.”&nbsp; As per Mr. Abay. R. K, the Managing Director of DPA&nbsp; “Salavation series was the best investment we could have&nbsp; made. This is the office Luminaire we’ve been waiting for.”</p>



<p><strong>Volume 11 Issue 4, April 2022&nbsp;</strong><br><strong><a href="https://www.ijsr.net/" target="_blank" rel="noreferrer noopener">www.ijsr.net</a>&nbsp;</strong><br>Licensed Under Creative Commons Attribution CC BY&nbsp;<br>Paper ID: SR22416151122 DOI: 10.21275/SR22416151122 811</p>



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<figure class="wp-block-image size-full"><img decoding="async" width="250" height="250" src="https://innohealthmagazine.comwp-content/uploads/2022/05/Girish-Bhardwaj.png" alt="Girish Bhardwaj" class="wp-image-13972" srcset="https://innohealthmagazine.com/wp-content/uploads/2022/05/Girish-Bhardwaj.png 250w, https://innohealthmagazine.com/wp-content/uploads/2022/05/Girish-Bhardwaj-150x150.png 150w, https://innohealthmagazine.com/wp-content/uploads/2022/05/Girish-Bhardwaj-100x100.png 100w, https://innohealthmagazine.com/wp-content/uploads/2022/05/Girish-Bhardwaj-140x140.png 140w" sizes="(max-width: 250px) 100vw, 250px" /></figure>
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<p style="color: #ffffff;"><em><strong>Composed by: &#8220;Girish Bhardwaj is an Inventor, Author, Entrepreneur, Engineer, Lighting Therapist, Educationist, Lighting and Wellbeing Advisor with the experience of 25 years!&#8221;<br>
<a href="https://www.girishbh.com/" target="_blank" rel="noopener">www.girishbh.com</a></strong></em></p>
</div>
</div>
<p>The post <a href="https://innohealthmagazine.com/2022/advertorial/grb-ijsr-salvation-office-light-case-study/">GRB IJSR SALVATION office Light  Case Study</a> appeared first on <a href="https://innohealthmagazine.com">InnoHEALTH magazine</a>.</p>
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		<title>InnoBRIDGE Sweden 2019 : Report</title>
		<link>https://innohealthmagazine.com/2019/innobridge/innobridge-sweden-2019/</link>
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		<dc:creator><![CDATA[InnoHEALTH Magazine]]></dc:creator>
		<pubDate>Fri, 31 May 2019 04:56:06 +0000</pubDate>
				<category><![CDATA[InnoBRIDGE]]></category>
		<category><![CDATA[AI]]></category>
		<category><![CDATA[Artificial Intelligence]]></category>
		<category><![CDATA[Climate Change]]></category>
		<category><![CDATA[delegation]]></category>
		<category><![CDATA[Health IT]]></category>
		<category><![CDATA[Health-tech]]></category>
		<category><![CDATA[healthcare]]></category>
		<category><![CDATA[healthcare collaboration]]></category>
		<category><![CDATA[Healthcare Innovation]]></category>
		<category><![CDATA[heslth technology]]></category>
		<category><![CDATA[Homecare]]></category>
		<category><![CDATA[India]]></category>
		<category><![CDATA[innovation]]></category>
		<category><![CDATA[innovation policy]]></category>
		<category><![CDATA[Internet of Things]]></category>
		<category><![CDATA[IoT]]></category>
		<category><![CDATA[medical university]]></category>
		<category><![CDATA[Medicine]]></category>
		<category><![CDATA[Mental Health]]></category>
		<category><![CDATA[Pharmaceuticals]]></category>
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		<category><![CDATA[Radiology]]></category>
		<category><![CDATA[Robotics]]></category>
		<category><![CDATA[Startup]]></category>
		<category><![CDATA[swecare]]></category>
		<category><![CDATA[Sweden]]></category>
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					<description><![CDATA[<p>A report on InnoBRIDGE Sweden 2019 that activised an Indian delegation to Sweden between the dates 20 - 24 May 2019. Know more about the delegation visit.</p>
<p>The post <a href="https://innohealthmagazine.com/2019/innobridge/innobridge-sweden-2019/">InnoBRIDGE Sweden 2019 : Report</a> appeared first on <a href="https://innohealthmagazine.com">InnoHEALTH magazine</a>.</p>
]]></description>
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			<h3 style="text-align: left" class="vc_custom_heading vc_do_custom_heading" >Executive summary</h3>
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	<p class="text-justify">InnoBRIDGE is an initiative of ​InnovatioCuris (IC) along with Swedish partners, Swecare and Business Region Gothenburg, ​where the primary aim is to create a seamless access platform for the Indian healthcare stakeholders to the Swedish healthcare stakeholders, to strengthen healthcare collaboration between Indian healthcare organizations and the Swedish organizations and showcase the best of Swedish healthcare to the Indian delegates.</p>
<h4>Innovation unit in Hospitals</h4>
<p class="text-justify">The hospitals that we visited had an innovation unit running over ten years and have formalized the innovation process. From sourcing of unmet needs from stakeholders (patients, care providers etc) to running of an innovation marathon. Such an intervention can be beneficial for hospitals in India and a collaboration can be sought from interested Swedish hospitals to launch such trainings and innovation programs.</p>
<h4>Developing healthcare AI</h4>
<p class="text-justify">Through the intervention of innovation units in hospitals and county level regional initiatives, Swedish agencies are evolving the understanding of developing AI solutions. With possibilities to pay with data to develop AI tools, hands-on experiments about trying latest AI tools to build an informative position are some of the considerations already being made at the Swedish end. There is a natural synergy between India and Sweden on the topic of AI<sup><a href="https://vgrblogg.se/utveckling/2018/12/19/ai-in-healthcare/" target="_blank" rel="nofollow noopener noreferrer">[1]</a></sup>. India can offer data to build AI and can gain from the Swedish expertise of processes and considerations to be made for collecting and refining data. These synergies were discussed at the India Nordic Seminar by stakeholders in detail from both sides.</p>
<h4>New Innovation Model of large private companies to incubate SMEs</h4>
<p class="text-justify">A path breaking innovation model, which is experimented by AstraZeneca in form of AZ Bioventures at their Gothenborg site was a key showcase of the visit. Home to some 30 SMEs for last 5 years, the model has already resulted in 5 Initial Public Offers to some billion dollar successes. The model was discussed in last year’s Davos Summit<sup><a href="https://innovator.news/an-antidote-for-the-incumbents-curse-5f477dbf0510" target="_blank" rel="nofollow noopener noreferrer">[2]</a></sup> and now actively being taken up by other corporates like ABB, Volvo in Sweden and AkzoNobel in Netherlands as an inspiration to unlock innovation in the ecosystem.</p>
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	<p><strong>Also Read:</strong><br />
<a href="https://innohealthmagazine.compersona/sweden-india-collaboration-health-sector/">Sweden-India Collaboration in Health Sector</a><br />
<a href="https://innohealthmagazine.comblog/indo-swedish-collaboration/">Indo-Swedish Collaboration</a></p>
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			<h3 style="text-align: left" class="vc_custom_heading vc_do_custom_heading" >Day 1</h3><div class="img-with-aniamtion-wrap " data-max-width="100%" data-max-width-mobile="100%" data-shadow="none" data-animation="fade-in" >
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            <img decoding="async" class="img-with-animation skip-lazy" data-delay="0" height="1228" width="1652" data-animation="fade-in" src="https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-1-Indian-delegation-with-Swecare-members-at-H2-Health-Hub.jpg" alt="Figure 1 - Indian delegation with Swecare members at H2 Health Hub" srcset="https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-1-Indian-delegation-with-Swecare-members-at-H2-Health-Hub.jpg 1652w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-1-Indian-delegation-with-Swecare-members-at-H2-Health-Hub-300x223.jpg 300w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-1-Indian-delegation-with-Swecare-members-at-H2-Health-Hub-1024x761.jpg 1024w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-1-Indian-delegation-with-Swecare-members-at-H2-Health-Hub-768x571.jpg 768w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-1-Indian-delegation-with-Swecare-members-at-H2-Health-Hub-1536x1142.jpg 1536w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-1-Indian-delegation-with-Swecare-members-at-H2-Health-Hub-1200x892.jpg 1200w" sizes="(max-width: 1652px) 100vw, 1652px" />
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	<pre class="text-justify">Figure 1 - Indian delegation with Swecare members at H2 Health Hub</pre>
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	<p class="text-justify">The visit started with a visit to H2 Health Hub in Stockholm which is a coworking space where Nordic Health Tech startups can connect, collaborate and share their innovations. Currently, there are 45 startups representing 26 countries in this space. The Indian delegation met representatives from the Swedish Ministry of Health, Swecare, SMEs and startups comprising of medical technologies, wellness, Health IT, mental health, pharmaceutical, radiology solutions, etc. The Sweden Ministry of Health representative shared his views on how Sweden is facilitating cross-border collaboration with India by using innovation to increase social impact such as the 10-years MoU signed between Sweden and AIIMS Jodhpur aimed at learning and exchanging best practices. The discussion also pointed out the India-Sweden collaborative industrial research and development program between Vinnova (Swedish government agency) and GITA (executing organization under the Department of Science and Technology, India). The collaboration aims at innovation projects linked to addressing global challenges such as climate change and sustainable developments.</p>
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            <img decoding="async" class="img-with-animation skip-lazy" data-delay="0" height="1236" width="1644" data-animation="fade-in" src="https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-2-Visit-to-EMPE-diagnostics-at-Karolinska-Institute-Campus.jpg" alt="Figure 2 - Visit to EMPE diagnostics at Karolinska Institute Campus" srcset="https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-2-Visit-to-EMPE-diagnostics-at-Karolinska-Institute-Campus.jpg 1644w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-2-Visit-to-EMPE-diagnostics-at-Karolinska-Institute-Campus-300x226.jpg 300w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-2-Visit-to-EMPE-diagnostics-at-Karolinska-Institute-Campus-1024x770.jpg 1024w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-2-Visit-to-EMPE-diagnostics-at-Karolinska-Institute-Campus-768x577.jpg 768w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-2-Visit-to-EMPE-diagnostics-at-Karolinska-Institute-Campus-1536x1155.jpg 1536w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-2-Visit-to-EMPE-diagnostics-at-Karolinska-Institute-Campus-1200x902.jpg 1200w" sizes="(max-width: 1644px) 100vw, 1644px" />
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	<pre>Figure 2 - Visit to EMPE diagnostics at Karolinska Institute Campus</pre>
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	<p class="text-justify">The Indian delegates got an opportunity to go around the Karolinska Institute (KI), Sweden’s largest medical university, and academic research center. Since 1901, the Nobel Assembly at KI has selected the Nobel laureates in Physiology or Medicine. The prime institute has university hospital, science park and innovation center. EMPE diagnostics which has background from KI and in collaboration with KI researchers presented their rapid diagnostic solution for Tuberculosis (Tb). The test uses DNA sequencing which can correctly identify virus or bacteria and their antimicrobial resistance within 2 hrs. India has around 86,000 new cases of Tb per day and 1.7 billion people at risk. Considering these statistics, EMPE through InnovatioCuris (IC) are looking forward to venture into the Indian market.</p>
<p class="text-justify">Next was a visit to Karolinska Hospital and its Innovation Unit which has collaboration with 8 EU countries. The Region Stockholm has a policy for innovation i.e. every organization should have an innovation center. The Innovation Center is a great model which encourage and engage all stakeholders, such as health professionals, patients, medical researchers and industrial partners to address unmet needs in hospital services through innovation. The innovation activities happen in day-to-day work at all levels and across each department. The center helps identify needs, define areas for innovation and develop the best solution. There is also a certification course for innovation leaders and managers. The center showcased project I-AID (Integrated AI Diagnostics) which aims to accelerate the development and implementation of artificial intelligence (AI) in healthcare initially focusing on medical imaging and physiology. This is a learning for Indian healthcare sector wherein the hospitals foster innovation in their own setting by creating an environment where ideas can become reality.</p>
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	<pre>Figure 3 - Indian delegation appreciating the serene and modern setting of Karolinska University Hospital</pre>
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	<p class="text-justify">A part of the Indian delegation also visited the Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU). Health Technology Assessment (HTA) involves systematic independent assessment of a method, including side-effects, cost-effectiveness, and ethical implications. SBU is one of the oldest organizations in the field of HTA and expressed interest in collaborating with India.</p>
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	<pre>Figure 4 - Indian delegation members with SBU Staff, Sophie Werko</pre>
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			<h3 style="text-align: left" class="vc_custom_heading vc_do_custom_heading" >Day 2</h3>
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	<p class="text-justify">The second day was in Uppsala, the fourth largest city in Sweden. Uppsala University is the oldest university in Sweden. The visit started with Region Uppsala where the delegation was welcomed by the chairman of the board, Vivianne Macdisi. Region Uppsala Innovation has a R&amp;D department for 2 hospitals, primary care centers, and mobile units. The ideas from employees, patients, and relatives are collected by each hospital unit’s idea coordinator. The ideas are assessed and approved by idea counsel. The feedback on the idea is conveyed to the ideator. Region Uppsala innovation also organizes a workshop called innovation race where companies and innovators such as employees generate ideas and work together towards the idea.</p>
<p class="text-justify">The county also has Uppsala Innovation Center (UIC) which is the world’s fourth-best university-affiliated business incubator. UIC offers business development programs and supports innovative startups and growth companies to commercialize, scale-up and access the international market. UIC provides expert help, awareness and knowledge for companies, and a national platform to connect the best companies.</p>
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	<pre>Figure 5 - Dr V K Singh from Indian delegation presented his healthcare innovation book to the chairman of Swecare board and Uppsala regional council, Ms Vivianne Macdisi</pre>
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	<p class="text-justify">The delegation had the opportunity to attend e-health matchmaking event, Vitalis which is the largest eHealth event in Scandinavian. Vitalis themes included Artificial Intelligence, IoT, Decision support, medical imaging, home care, elderly care, remote health care, and robotics.</p>
<p class="text-justify">The Business Region Gothenburg and Swecare organized a special seminar ‘AI and Collaborations in AI and Innovation’<sup><a href="https://app.emarketeer.com/a/plink/row/v1-t13j3SHcM7SCX6ygNzUJUiMqxTwOCm~WfnKJM4whr~M.html" target="_blank" rel="nofollow noopener noreferrer">[3]</a></sup>. The keynote speech was given by Linda Swirtun, program manager of Vinnova, Sweden’s government agency for innovation. Vinnova funds healthcare/life sciences innovation projects and research by collaborating internationally. Under the Swedish- Indian Innovation Partnership, the Swedish companies can collaborate with companies in India in joint research and innovation projects to address global challenges such as climate change and sustainable development. The corporate-driven collaborations can be in the area of smart cities and clean technologies, digitalization, and IoT.</p>
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	<pre>Figure 6 - Linda Swirtun sharing the first keynote about India Sweden Collaboration</pre>
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	<p class="text-justify">The panel discussions had representatives from the Nordic-Baltic region and India. The first panel focused on the transnational collaborations between the two regions and its challenges. Rohini Pimple, RICH, Dr V K Singh, InnovatioCuris,  Dr Sandeep Bhalla, PHFI, Kingshuk Poddar, Medivalley Incubator represented the Indian side. Lars Lindskold, Swelife AI Institute, Iris Ohrn, Business Region Gothenburg, Jaanus Pikani, Scanbalt Forum and Magnus Bjorsne, AZ BioVenturehub represented the Nordic Baltic side. The session was moderated by Shampa Bari of Swecare. The Indian panelist discussed how the current government has been very supportive and driving innovation in all sectors. There have been changes in policies and regulations which has led to a smooth process for collaborations. India has huge data which can be used to develop AI tools by countries like Sweden. Also, knowledge sharing between the regions could be beneficial. The panelist further discussed the unmet needs, and public-private partnership models working in India. The research cluster of India shared the opportunities of life sciences. The government incubation center shared how it can be a soft-landing spot for Nordic-Baltic companies for medical devices. The representative from the Public Health Foundation of India discussed the challenges in public health in India and how capacity building can be done at scale. The Nordic-Baltic panelist emphasized on the various technologies which are relevant for India. In addition, the representative from Business Region Gothenburg stated that it is easier to do research collaboration – to test and validate one’s product in Sweden as compared to others. Furthermore, the Nordic/Baltic region has a strong IP protection regime. Therefore, the collaboration will be a win-win situation for both the regions.</p>
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	<pre class="text-justify">Figure 7 - First panel had regions and clusters from both sides discussing collaboration</pre>
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	<p class="text-justify">The second panel brought together hands-on experts on AI both from the developer and user side. Indian side was represented by Pradeep Mathapati, HCL, Deepali Jetley, Qwazent Healthcare. Swedish side was represented by Annie Chandy from LUDC, Devdatt Dhubhashi from Chalmers University of Technology and Peter Soderman from Karolinska University Hospital. The session was moderated by Sachin Gaur from InnovatioCuris. The panel discussed in depth the challenges of AI development and how processes are evolving at the end of the health system to collect and refine data. Interesting observations were made on the role of data in AI, future job roles for AI in health sector and business models that may emerge when the providers and IT players collaborate.</p>
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	<pre class="text-justify">Figure 8 - Panel 2 keynote was shared by Pradeep Mathapati from HCL Germany office</pre>
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	<p class="text-justify">The last day gave a perspective about the second largest city of Sweden, Gothenburg. The delegation was welcomed by Business Region Gothenburg, West Swedish Chamber of Commerce, and Surgical Science. Surgical Science have virtual reality simulators for surgeries like evidence-based laparoscopic and endoscopic training. The representative of West Swedish Chamber of Commerce discussed why Sweden is interested in investing in India as it is an emerging market after China, and it is a volume market with rich data. India also has a large pool of highly skilled IT professionals. On the other hand, Sweden is one of the world’s largest 10 economies and has become one of the most innovative countries in the world. Sweden is home to companies like Volvo, Ericsson, SKF, Spotify, Skype, IKEA, etc. The Indian team visited the Sahlgrenska University hospital along with Gothia Forum, which has 54 clinics in West Sweden for clinical trials.</p>
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	<pre class="text-justify">Figure 9 - Expert from Surgical Science ready to give us a handson training on various surgeries (ofcourse simulated)</pre>
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	<p class="text-justify">Furthermore we visited Biobank West, a Swedish Biobank showed their infrastructure where they store the blood and tissue samples. Companies such as Surgical Science, Biobank West are actively looking out for collaboration with India.</p>
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	<pre class="text-justify">Figure 10 - Site visit of Gothia Forum, Swedish Bio Bank</pre>
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	<p class="text-justify">The last stop was at the famous Swedish pharmaceutical company Astra Zeneca (AZ) which has been ranked number one in IDEA Pharma’s Pharmaceutical Innovation Index (PII). An interesting model has been adopted by AZ called AZ BioVenture Hub. It is a collaborative innovation ecosystem for emerging biotech, medtech companies, and academic groups to strengthen competitiveness in the Nordic life science industry. AZ provides space to the SMEs and an opportunity to interact with highly-skilled AZ professionals. In addition, the SMEs can use the state-of-the-art lab facilities and infrastructure of AZ. Currently, there are thirty companies in the AZ BioVenture Hub.</p>
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	<pre class="text-justify">Figure 11 - Indian delegation with Magnus, Pernila and Jesper from AZ BioVentures and GoCo City</pre>
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	<p class="text-justify">AZ has also enabled a bigger initiative called as GoCo Health Innovation City. GoCo will be a collaborative innovation ecosystem with more than 30 companies working in biotech, medtech, and academia. This city will be completed in eight years and will have co-innovation programs and services such as networking events, experienced facilitators to mentor the innovator, connecting members with similar challenges, growth guides. It will be a place for focused work and healthy living.</p>
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            <img decoding="async" class="img-with-animation skip-lazy" data-delay="0" height="876" width="1640" data-animation="fade-in" src="https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-10-Site-visit-of-Gothia-Forum-Swedish-Bio-Bank.jpg" alt="Figure 12: Field visit to the site of planned GoCo Health City" srcset="https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-10-Site-visit-of-Gothia-Forum-Swedish-Bio-Bank.jpg 1640w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-10-Site-visit-of-Gothia-Forum-Swedish-Bio-Bank-300x160.jpg 300w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-10-Site-visit-of-Gothia-Forum-Swedish-Bio-Bank-1024x547.jpg 1024w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-10-Site-visit-of-Gothia-Forum-Swedish-Bio-Bank-768x410.jpg 768w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-10-Site-visit-of-Gothia-Forum-Swedish-Bio-Bank-1536x820.jpg 1536w, https://innohealthmagazine.com/wp-content/uploads/2019/05/Figure-10-Site-visit-of-Gothia-Forum-Swedish-Bio-Bank-1200x641.jpg 1200w" sizes="(max-width: 1640px) 100vw, 1640px" />
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	<pre class="text-justify">Figure 12 - Field visit to the site of planned GoCo Health City</pre>
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	<p class="text-justify">Sweden being the global innovation leader and start-up hotbed can be a great example for India. The country has an innovation policy and each county is working towards it. It is focusing on the unmet needs of the population and fostering a culture of innovation. The Swedish innovations can be plugged into the Indian ecosystem and vice versa. Innovation is fostered by opening boundaries, by gathering insights and information from new connections, and by sharing knowledge. Keeping this in mind, InnoBRIDGE was envisioned and continuously working towards other collaborations.</p>
<p class="text-justify">We look forward to build on the initial interests among stakeholders from both sides in form of knowledge webinars, physical visits and signing of MoUs in cases of where the concrete plans emerge. The next milestone for us would be InnoHEALTH 2019, 4-5 October where interested Swedish stakeholders plan to visit us in India and hopefully by then we would have progressed on some of the existing discussions. Also, some of our Indian delegates look forward to participate in Vitalis next year!</p>
<p>&nbsp;<br />
Send your comments / feedback to <a href="mailto:sachin@innovatiocuris.com"><strong>sachin@innovatiocuris.com</strong></a></p>
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	<h3>References</h3>
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	<ul>
<li><sup>[1]</sup> <a href="https://vgrblogg.se/utveckling/2018/12/19/ai-in-healthcare/" target="_blank" rel="noopener noreferrer"><strong>https://vgrblogg.se/utveckling/2018/12/19/ai-in-healthcare/</strong></a></li>
<li><sup>[2] </sup><a href="https://innovator.news/an-antidote-for-the-incumbents-curse-5f477dbf0510" target="_blank" rel="noopener noreferrer"><strong>https://innovator.news/an-antidote-for-the-incumbents-curse-5f477dbf0510</strong></a></li>
<li><sup>[3] </sup><a href="https://app.emarketeer.com/a/plink/row/v1-t13j3SHcM7SCX6ygNzUJUiMqxTwOCm~WfnKJM4whr~M.html" target="_blank" rel="noopener noreferrer"><strong>https://app.emarketeer.com/a/plink/row/v1-t13j3SHcM7SCX6ygNzUJUiMqxTwOCm~WfnKJM4whr~M.html</strong></a></li>
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	<p>To know more about the InnoBRIDGE Sweden 2019 program and details of Indian delegation, you may visit <a href="http://innovatiocuris.com/innobridge/innobridge-2019/" target="_blank" rel="noopener noreferrer"><strong>innovatiocuris.com/innobridge/innobridge-2019</strong></a></p>
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	<p><a href="https://innohealthmagazine.com" target="_blank" rel="noopener noreferrer"><strong>Back to home</strong></a></p>
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<p>The post <a href="https://innohealthmagazine.com/2019/innobridge/innobridge-sweden-2019/">InnoBRIDGE Sweden 2019 : Report</a> appeared first on <a href="https://innohealthmagazine.com">InnoHEALTH magazine</a>.</p>
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		<title>Aspirin to Aspiration</title>
		<link>https://innohealthmagazine.com/2018/newscope/aspirin-to-aspiration/</link>
					<comments>https://innohealthmagazine.com/2018/newscope/aspirin-to-aspiration/#comments</comments>
		
		<dc:creator><![CDATA[InnoHEALTH Magazine]]></dc:creator>
		<pubDate>Wed, 21 Nov 2018 05:55:29 +0000</pubDate>
				<category><![CDATA[Newscope]]></category>
		<category><![CDATA[alexander flemming]]></category>
		<category><![CDATA[Aspiration]]></category>
		<category><![CDATA[Aspirin]]></category>
		<category><![CDATA[Ayurveda]]></category>
		<category><![CDATA[casual organisms]]></category>
		<category><![CDATA[Development]]></category>
		<category><![CDATA[discovery]]></category>
		<category><![CDATA[Drug]]></category>
		<category><![CDATA[Drug testing industry]]></category>
		<category><![CDATA[Giza]]></category>
		<category><![CDATA[healthcare]]></category>
		<category><![CDATA[Healthcare Innovation]]></category>
		<category><![CDATA[herbal condiments]]></category>
		<category><![CDATA[hindu veda scriptures]]></category>
		<category><![CDATA[innovation]]></category>
		<category><![CDATA[international economy]]></category>
		<category><![CDATA[lung disorder]]></category>
		<category><![CDATA[Medication]]></category>
		<category><![CDATA[Medicines]]></category>
		<category><![CDATA[Mutation]]></category>
		<category><![CDATA[parasites]]></category>
		<category><![CDATA[penicillin]]></category>
		<category><![CDATA[Pharma Industry]]></category>
		<category><![CDATA[Pharmaceutical]]></category>
		<category><![CDATA[Physiology]]></category>
		<category><![CDATA[stone age]]></category>
		<category><![CDATA[streptococci bacterium]]></category>
		<category><![CDATA[Surgery]]></category>
		<category><![CDATA[Technology]]></category>
		<category><![CDATA[Trescon]]></category>
		<guid isPermaLink="false">https://ztt.nrm.mybluehostin.me/innohealthmagazine?p=4903</guid>

					<description><![CDATA[<p>3 Facts that pushed an industry from ASPIRIN to ASPIRATION.  How technology and innovation will drive the Pharma industry? </p>
<p>The post <a href="https://innohealthmagazine.com/2018/newscope/aspirin-to-aspiration/">Aspirin to Aspiration</a> appeared first on <a href="https://innohealthmagazine.com">InnoHEALTH magazine</a>.</p>
]]></description>
										<content:encoded><![CDATA[<div id="fws_69aa6cab52baa"  data-column-margin="default" data-midnight="dark"  class="wpb_row vc_row-fluid vc_row"  style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop"  style=""></div></div></div><div class="row_col_wrap_12 col span_12 dark ">
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	<p>3 Facts that pushed an industry from <strong>ASPIRIN</strong> to <strong>ASPIRATION</strong></p>
<p style="text-align: justify !important;">How <a href="https://innohealthmagazine.cominnohealth-conference/innaugral-innohealth-2018/">technology and innovation</a> will drive the <a href="https://innohealthmagazine.cominnohealth-conference/biotech-medical-devices-and-future-technologies/">Pharma industry</a>? Ever since the pyramids were erected in Giza, the need for medication and surgery were required. During the Stone Age, as early as 3,300 BC, studies have shown that primitive forms of herbal condiments were used to treat wounds and certain lung disorders. <a href="https://innohealthmagazine.comwell-being/mother-of-all-healings/">Ayurveda</a>, from the annals of the Hindu Veda scriptures, can be traced back to almost 4,000 BC.</p>
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	<p style="text-align: justify !important;">The first institution to train individuals in the field of physiology and <a href="https://innohealthmagazine.comtrends/pill-to-determine-medication-ingestion/">medication</a> was established in Italy, around the 15th century.</p>
<p style="text-align: justify !important;">Although the first landmark in the healthcare industry was the accidental discovery of Penicillin by Scottish scientist Alexander Fleming, in the year 1928; the widespread use of Penicillin was initiated only in 1942 to treat infections caused by Streptococci Bacterium. But over time, Penicillin-resistant bacteria began to come to life.</p>
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	<p style="text-align: justify !important;">And it wasn’t an isolated situation, as overtime viruses and parasites begun mutating and developing resistance over their target medication that it became important to continuously develop more advanced strains of medicines, and this sparked off the birth of the Pharmaceutical and Drug testing industry!</p>
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	<p style="text-align: justify !important;">In 2018, the pharmaceutical industry is one of the top 3 industries in the world. In 2017, the pharmaceutical industry pumped nearly USD 24 bill into advertising and PR, with USD 12 bill from the United States alone!</p>
<p style="text-align: justify !important;">The industry invests nearly USD 40 bill a year on drug development and clinical trials, making it one of the biggest contributors to the international economy.</p>
<p style="text-align: justify !important;">The need for constant innovation and development of drugs has risen drastically over the last 15 years. The growth spurt arose due to the birth of certain strains of bacterium and viruses that have begun adapting to the medication. As the causal organisms began to adapt to the quintessential drugs, the industry had to keep researching drugs to fight this mutation.</p>
<p><strong>(By Trescon)</strong></p>
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<p>The post <a href="https://innohealthmagazine.com/2018/newscope/aspirin-to-aspiration/">Aspirin to Aspiration</a> appeared first on <a href="https://innohealthmagazine.com">InnoHEALTH magazine</a>.</p>
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		<post-id xmlns="com-wordpress:feed-additions:1">4903</post-id>	</item>
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		<title>Molecular mechanics controlling the circadian rhtythm</title>
		<link>https://innohealthmagazine.com/2018/persona/molecular-mechanism/</link>
					<comments>https://innohealthmagazine.com/2018/persona/molecular-mechanism/#respond</comments>
		
		<dc:creator><![CDATA[InnoHEALTH Magazine]]></dc:creator>
		<pubDate>Wed, 07 Feb 2018 07:26:27 +0000</pubDate>
				<category><![CDATA[Persona]]></category>
		<category><![CDATA[Astronomer Jean Jacques d'Ortous de Mairan]]></category>
		<category><![CDATA[Biological Clock]]></category>
		<category><![CDATA[Biological Rhythm]]></category>
		<category><![CDATA[Boston]]></category>
		<category><![CDATA[Brandeis University]]></category>
		<category><![CDATA[Cell Nucleus]]></category>
		<category><![CDATA[Ciradian Rhythm]]></category>
		<category><![CDATA[Circadianrhythm]]></category>
		<category><![CDATA[Clock Gene]]></category>
		<category><![CDATA[Cytoplasm]]></category>
		<category><![CDATA[DBT]]></category>
		<category><![CDATA[Dynamic Research]]></category>
		<category><![CDATA[Dynamic Trio]]></category>
		<category><![CDATA[External Environment]]></category>
		<category><![CDATA[Health and wellbeing]]></category>
		<category><![CDATA[Hormone Level]]></category>
		<category><![CDATA[Human Physiology]]></category>
		<category><![CDATA[Inner Clock]]></category>
		<category><![CDATA[Jeffrey C. Hall]]></category>
		<category><![CDATA[Jet lag]]></category>
		<category><![CDATA[Mechanistic Principles]]></category>
		<category><![CDATA[Metabolism]]></category>
		<category><![CDATA[Micheal Rosbash]]></category>
		<category><![CDATA[Micheal W. Young]]></category>
		<category><![CDATA[Mimosa Plant]]></category>
		<category><![CDATA[Mimosa Plants]]></category>
		<category><![CDATA[Molecular Components]]></category>
		<category><![CDATA[Molecular Mechanisms]]></category>
		<category><![CDATA[mRNA]]></category>
		<category><![CDATA[Multi-cellular organism]]></category>
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		<category><![CDATA[Nobel Prize Winner]]></category>
		<category><![CDATA[Noble Prize]]></category>
		<category><![CDATA[PER]]></category>
		<category><![CDATA[Physiology]]></category>
		<category><![CDATA[Rockefeller University]]></category>
		<category><![CDATA[Ronald Konopka]]></category>
		<category><![CDATA[Seymour Benzer]]></category>
		<category><![CDATA[TIM]]></category>
		<guid isPermaLink="false">https://ztt.nrm.mybluehostin.me/innohealthmagazine?p=3257</guid>

					<description><![CDATA[<p>For many years we have known that living organisms, including humans, have an internal, biological clock that helps them anticipate and adapt to the regular rhythm of the day. Jeffrey C. Hall, Michael W. Young and Michael Rosbash 2017 Nobel Prize winners discovered molecular mechanism controlling the circadian rhythm</p>
<p>The post <a href="https://innohealthmagazine.com/2018/persona/molecular-mechanism/">Molecular mechanics controlling the circadian rhtythm</a> appeared first on <a href="https://innohealthmagazine.com">InnoHEALTH magazine</a>.</p>
]]></description>
										<content:encoded><![CDATA[<div id="fws_69aa6cab54f03"  data-column-margin="default" data-midnight="dark"  class="wpb_row vc_row-fluid vc_row"  style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop"  style=""></div></div></div><div class="row_col_wrap_12 col span_12 dark ">
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	<p style="text-align: justify !important;">Jeffrey C. Hall, Michael W. Young and Michael Rosbash 2017 Nobel Prize winners in Physiology or Medicine. Honored for their discoveries of molecular mechanisms controlling the circadian rhythm.</p>
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	<p style="text-align: justify !important;">Life on Earth is adapted to the rotation of our planet. For many years we have known that living organisms, including humans, have an internal, biological clock that helps them anticipate and adapt to the regular rhythm of the day. But how does this clock actually work? Jeffrey C. Hall, Michael Rosbash and Michael W. Young were able to peek inside our biological clock and elucidate its inner workings. Their discoveries explain how plants, animals and humans adapt their biological rhythm so that it is synchronized with the Earth’s revolutions.</p>
<p style="text-align: justify !important;">Using fruit flies as a model Honored for their discoveries of molecular mechanisms controlling the circadian rhythm organism, this year’s Nobel laureates isolated a gene that controls the normal daily biological rhythm. They showed that this gene encodes a protein that accumulates in the cell during the night, and is then degraded during the day. Subsequently, they identified additional protein components of this machinery, exposing the mechanism governing the self-sustaining clockwork inside the cell. We now recognize that biological clocks function by the same principles in cells of other multi-cellular organisms, including humans.</p>
<p style="text-align: justify !important;">With exquisite precision, our inner clock adapts our physiology to the dramatically different phases of the day. The clock regulates critical functions such as behavior, hormone levels, sleep, body temperature and metabolism. Our wellbeing is affected when there is a temporary mismatch between our external environment and this internal biological clock, for example when we travel across several time zones and experience “jet lag”. There are also indications that chronic misalignment between our lifestyle and the rhythm dictated by our inner timekeeper is associated with increased risk for various diseases.</p>
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	<p><span style="color: #0071b2;"><strong>Our inner clock</strong></span></p>
<p style="text-align: justify !important;">Most living organisms anticipate and adapt to daily changes in the environment. During the 18th century, the astronomer Jean Jacques d’Ortous de Mairan studied mimosa plants, and found that the leaves opened towards the sun during daytime and closed at dusk. He wondered what would happen if the plant was placed in constant darkness. He found that independent of daily sunlight the leaves continued to follow their normal daily oscillation (See figure). Plants seemed to have their own biological clock.</p>
<p style="text-align: justify !important;">Other researchers found that not only plants, but also animals and humans, have a biological clock that helps to prepare our physiology for the fluctuations of the day. This regular adaptation is referred to as the circadianrhythm, originating from the Latin words circa meaning “around” and diesmeaning “day”. But just how our internal circadian biological clock worked remained a mystery.</p>
<p><span style="color: #0071b2;"><strong>Identification of a clock gene</strong></span></p>
<p style="text-align: justify !important;">During the 1970’s, Seymour Benzer and his student Ronald Konopka asked whether it would be possible to identify genes that control the circadian rhythm in fruit flies. They demonstrated that mutations in an unknown gene disrupted the circadian clock of flies. They named this gene period. But how could this gene influence the circadian rhythm?</p>
<p style="text-align: justify !important;">This year’s Nobel Laureates, who were also studying fruit flies, aimed to discover how the clock actually works. In 1984, Jeffrey Hall and Michael Rosbash, working in close collaboration at Brandeis University in Boston, and Michael Young at the Rockefeller University in New York, succeeded in isolating the period gene. Jeffrey Hall and Michael Rosbash then went on to discover that PER, the protein encoded by period, accumulated during the night and was degraded during the day. Thus, PER protein levels oscillate over a 24-hour cycle, in synchrony with the circadian rhythm.</p>
<p><strong><span style="color: #0071b2;">A self-regulating clockwork mechanism</span></strong></p>
<p style="text-align: justify !important;">The next key goal was to understand how such circadian oscillations could be generated and sustained. Jeffrey Hall and Michael Rosbash hypothesized that the PER protein blocked the activity of the period gene. They reasoned that by an inhibitory feedback loop, PER protein could prevent its own synthesis and thereby regulate its own level in a continuous, cyclic rhythm.</p>
<p style="text-align: justify !important;">The model was tantalizing, but a few pieces of the puzzle were missing. To block the activity of the period gene, PER protein, which is produced in the cytoplasm, would have to reach the cell nucleus, where the genetic material is located. Jeffrey Hall and Michael Rosbash had shown that PER protein builds up in the nucleus during night, but how did it get there? In 1994 Michael Young discovered a second clock gene, timeless, encoding the TIM protein that was required for a normal circadian rhythm. In elegant work, he showed that when TIM bound to PER, the two proteins were able to enter the cell nucleus where they blocked period gene activity to close the inhibitory feedback loop.</p>
<p style="text-align: justify !important;">Such a regulatory feedback mechanism explained how this oscillation of cellular protein levels emerged, but questions lingered. What controlled the frequency of the oscillations? Michael Young identified yet another gene, double time, encoding the DBT protein that delayed the accumulation of the PER protein. This provided insight into how an oscillation is adjusted to more closely match a 24-hour cycle.</p>
<p style="text-align: justify !important;">The paradigm-shifting discoveries by the laureates established key mechanistic principles for the biological clock. During the following years other molecular components of the clockwork mechanism were elucidated, explaining its stability and function. For example, this year’s laureates identified additional proteins required for the activation of the period gene, as well as for the mechanism by which light can synchronize the clock.</p>
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	<p><span style="color: #0071b2;"><strong>Keeping time on our human physiology</strong></span></p>
<p style="text-align: justify !important;">The biological clock is involved in many aspects of our complex physiology. We now know that all multicellular organisms, including humans, utilize a similar mechanism to control circadian rhythms. A large proportion of our genes are regulated by the biological clock and, consequently, a carefully calibrated circadian rhythm circadian biology has developed into a vast and highly dynamic research field, with implications for our health and wellbeing.</p>
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<p>The post <a href="https://innohealthmagazine.com/2018/persona/molecular-mechanism/">Molecular mechanics controlling the circadian rhtythm</a> appeared first on <a href="https://innohealthmagazine.com">InnoHEALTH magazine</a>.</p>
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